Cleaning up the terrible Kindle UI.
Unsubscribe from special offers
Use this Amazon help page to find out how to disable ads in your device. It will cost you around $20, but it's so worth it. Your attention is more valuable than that.
Disable the cluttered 'Home screen view'
Go to Settings > Device Options > Personalize your Kindle > Advanced Options > and turn 'Home Screen View' off.
Delete any book you are not planning to read in the next 6 months. Seriously, do it. You can always redownload them anyway.
Remove noise with collections
Create collections and add your books there. Personally I have one collection for each category / interest I'm currently pursuing. For example, my current collections are:
I have scheduled time slots in my calendar to read a bit of each one of these collections. Besides it, I like to have a single book that I consider my 'current' book. I keep this book in a "Current collection".
Select the right filters
In your home screen, select the following filters:
Just downloaded items
Ordered by title
These considerations are now available as a blog post in Adventures in Consumer Technology.